Oncolytic Engineering of ICP34.5 and LAT of Herpes Simplex Virus Type 1
نویسندگان
چکیده
Oncolytic virus (OV) is a kind of that can preferentially infect and kill tumor cells. The second oncolytic drug was herpes simplex (oHSV) Talimogene Laherparepvec (T-VEC). HSV-1 infectious cell culture protein 34.5 (ICP34.5) latency-associated transcript (LAT) genes are closely related to selective infection latent infection. Their engineering essential for constructing efficient safe oHSV. We summarized the mechanisms ICP34.5 LAT in course reviewed engineered oHSVs. aimed provide an insight developing oHSV future.
منابع مشابه
Developing oncolytic Herpes simplex virus type 1 through UL39 knockout by CRISPR-Cas9
Objective(s): Oncolytic Herpes simplex virus type 1 (HSV-1) has emerged as a promising strategy for cancer therapy. However, development of novel oncolytic mutants has remained a major challenge owing to low efficiency of conventional genome editing methods. Recently, CRISPR-Cas9 has revolutionized genome editing.Materials and Methods: I...
متن کاملPrevalence of Herpes Simplex Virus type-1, 2 and Varicella Zoster Virus (VZV) in Eye Infection
Abstract Background and Aims: Herpes simplex virus (HSV) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. This study is aimed to provide an estimation of the incidence of Herpes Simplex Virustype-1, 2(HSV1, 2) and Varicella Zoster Virus (VZV) in tears and swab from eye infection by polymerase chain reaction (PCR) in eye ...
متن کاملAnti-viral Effect and Mechanism of Carvacrol on Herpes Simplex Virus Type 1
Background and Aims: Herpes simplex virus type 1 (HSV-1) belonging to herpes viridae family is a normal human pathogen with benign lesions in immunocompromised patients which creates serious problems. Acyclovir is used to treat herpetic infections. Because of developing drug-resistant strains, the use of medicinal plants and their related compounds with fewer side effects is considered for the ...
متن کاملThe Effect of Hydroalcoholic Extract of Olive Leaves against Herpes Simplex Virus Type 1
Background: It was shown that olive leave extract has antifungal, antibacterial and antiviral activities. The effects of OLE on herpes simplex virus-1 (HSV-1) have not been systematically investigated yet. The aim of this study was to examine the in vitro effect of olive leaf hydroalcoholic extract (OLHE) on HSV-1. Methods: Virucidal effect and viral replication in Vero cell line were studied i...
متن کاملApplication of McCoy Cell Line for Propagation of Herpes Simplex Virus Type 1
Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) are members of the Herpesviridae family. About 40% to 80% of the world populations are infected with HSV and its prevalence is high in Iran. The high prevalence of this virus in the community and the ability of the virus in causing fatal diseases among immunocompromised patients, have encouraged studies to be performed on HSV and suitable cell ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Yangtze medicine
سال: 2021
ISSN: ['2475-7349', '2475-7330']
DOI: https://doi.org/10.4236/ym.2021.52011